SLC22A3 (Q306) polyclonal antibody

Product Specifications

Background

Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT3, also known as extraneuronal monoamine transporter, is widely expressed in different regions of the brain including the hippocampus, cerebellum and cerebral cortex. OCT3 mediates the uptake of several neuroactive agents, including dopamine, and may play an important role in the disposition of neurotransmitters and cationic neurotoxins in the brain.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMT; Organic cation transporter 3; SLC22A3; EMTH; OCT3

Swiss Prot

O75751

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 281-330 of Human SLC22A3.

Conjugation

Unconjugated

Applications

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 61 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

SLC22A3 (Q306) polyclonal antibody detects endogenous levels of SLC22A3 protein.

Applications Notes

Western blot (WB) analysis of SLC22A3 (Q306) polyclonal antibody at 1:500 dilution Lane1:786-O whole cell lysate (40ug) Lane2:L02 whole cell lysate (40ug) Lane3:HEK293T whole cell lysate (40ug)