Nephrocystin-5 (R467) polyclonal antibody
Product Specifications
Background
The nephrocystin proteins comprise a family of five enzymes that commonly interact with p130Cas, proline-rich tyrosine kinases, calmodulin and tensin, indicating that these proteins may participate in a common signaling pathway. Localized to the outer segments and primary cilia of photoreceptor cells, nephrocystin-5 is complexed with RPGR (retinitis pigmentosa GTPase regulator) and interacts directly with calmodulin. Nephrocystin-5 is thought to participate with RPGR in a pathway of ciliary function in the kidey and retina. Mutations in the gene encoding nephrocystin-5 are the primary cause of Senior-Loken syndrome 5, a juvenile disorder characterized by defects in the waste filtering system of the kidney, as well as retinal degradation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
IQ calmodulin-binding motif-containing protein 1; Nephrocystin-5; p53 and DNA damage-regulated IQ motif protein; PIQ; IQCB1; KIAA0036; NPHP5; OK/SW-cl.85
Swiss Prot
Q15051
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 432-486 of Human Nephrocystin-5.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 69 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Nephrocystin-5 (R467) polyclonal antibody detects endogenous levels of Nephrocystin-5 protein.
Applications Notes
Western blot (WB) analysis of Nephrocystin-5 (R467) pAb at 1:1000 dilution Lane1:The Kidney tissue lysate of Mouse (5ug) Lane2:The Ovary tissue lysate of Rat (40ug) Lane3:HCT116 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
Curated Selection
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