CHP2 (M136) polyclonal antibody

Product Specifications

Background

Calcineurin B homologous protein 2, functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520; HCA520

Swiss Prot

O43745

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to Human CHP2.

Conjugation

Unconjugated

Applications

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodified

Molecular Weight

~ 23 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

CHP2 pAb detects endogenous levels of CHP2 protein.

Applications Notes

Western blot (WB) analysis of CHP2 (M136) Antibody at 1:500 dilution Lane1:HEK293T whole cell lysate (40ug) Lane2:MG63 whole cell lysate (40ug) Lane3:PC12 whole cell lysate (40ug) Lane4:AML-12 whole cell lysate (40ug)