AVP Receptor V2 (L111) polyclonal antibody

Product Specifications

Background

The human AVP receptor V2 gene maps to chromosome Xq28 and is expressed in lung and kidney. Mutations in the V2 receptor result in nephrogenic diabetes insipidus (NDI), a rare X-linked disorder characterized by the inability of the kidney to concentrate urine in response to AVP. The AVP Receptor V2 activates the Gs protein and the cyclic AMP second messenger system. The AVP Receptor V3 is preferentially expressed in the pituitary and stimulates the release of adrenocorticotropic hormone (ACTH) in response to AVP by mobilizing intracellular calcium stores. AVP receptor antagonists may have potential therapeutic effects in hypertension, congestive heart failure, nephrotic syndrome and ACTH-secreting tumors.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Vasopressin V2 receptor; V2R; AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor; AVPR2; ADHR; DIR; DIR3; V2R

Swiss Prot

P30518

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 80-130 of Human AVP Receptor V2.

Conjugation

Unconjugated

Applications

WB IF

Dilution

WB: 1:500~1:1000 IF: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 38 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

AVP Receptor V2 (L111) polyclonal antibody detects endogenous levels of AVP Receptor V2 protein.

Applications Notes

Western blot (WB) analysis of AVP Receptor V2 (L111) polyclonal antibody at 1:500 dilution Lane1:786-O whole cell lysate (40ug) Lane2:HEK293T whole cell lysate (40ug) Lane3:The kidney tissue lysate of Mouse (40ug) Lane4:The kidney tissue lysate of Rat (40ug) Lane5:PC12 whole cell lysate (40ug)