Cerebral 1 (L310) polyclonal antibody

Product Specifications

Background

Cerebral 1 also called hucep-1, KIAA0409 or RRP8, is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Ribosomal RNA-processing protein 8; Cerebral protein 1; Nucleomethylin; RRP8; KIAA0409; NML; hucep-1; HUCE1; hucep1; RRP-8

Swiss Prot

O43159

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 291-340 of Human Cerebral 1.

Conjugation

Unconjugated

Applications

IHC

Dilution

IHC:1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .