SIP1 (E101) polyclonal antibody
Product Specifications
Background
SIP1, also known as SMADIP1 and ZFHX1B, can be induced by TGFβ treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR) . Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease—all symptoms of HSCR.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Zinc finger E-box-binding homeobox 2; Smad-interacting protein 1; SMADIP1; Zinc finger homeobox protein 1b; ZEB2; KIAA0569; SIP1; ZFHX1B; ZFX1B; HRIHFB2411
Swiss Prot
O60315
Reactivity
Human, Mouse
Immunogen
Synthetic peptide, corresponding to amino acids 71-120 of Human SIP1.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 157 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SIP1 (E101) pAb detects endogenous levels of SIP1 protein.
Applications Notes
Western blot (WB) analysis of SIP1 (E101) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:HEK293T whole cell lysate Lane3:NIH-3T3 whole cell lysate
Host or Source
Rabbit
Available Sizes
Curated Selection
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