GNAZ (A12) polyclonal antibody

Product Specifications

Background

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. G protein z alpha, encoded by the GNAZ gene, is enriched in neural tissue and differs in sequence from other G alpha subunits. Alpha Subunits are encoded in 15 genes and several transcripts are alternatively spliced. Receptors may discriminate between splice variants; whether splice variants are functionally different in regulating effectors is not known. All alpha subunits appear to be palmitoylated near the N-terminus.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Guanine nucleotide-binding protein G (z) subunit alpha; G (x) alpha chain; Gz-alpha; GNAZ; Gzα; Gz-α

Swiss Prot

P19086

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to the N-terminus of Human GNAZ.

Conjugation

Unconjugated

Related Pathways

Phospholipase Signaling, SAPK JNK Signaling Cascades, G Protein-coupled Receptors Signaling to MAPK Erk

Applications

IHC

Dilution

IHC:1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .