Synphilin-1 (R846) polyclonal antibody

Synphilin-1 (α-synuclein interacting protein, SNCAIP) is a 919 amino acid protein that associates with α synuclein and promotes the formation of cytosolic inclusions in neuronal cells. The synuclein family members, including α-synuclein and β-synuclein, are predominantly expressed in the brain, where they influence synaptic regulation and neuronal plasticity. Synphilin-1 contains modular protein domains, such as ankyrin-like repeats and a coiled-coil domain.While both α-synuclein and synphilin-1 are coexpressed in Lewy bodies of patients with Parkinson’s disease, only mutations in the gene for α-synuclein have been determined to confer pathogenicity.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of Synphilin-1 (R846) pAb at 1:500 dilution Lane1:3T3-L1 whole cell lysate (40ug) Lane2:C6 whole cell lysate (40ug) Lane3:Hela whole cell lysate (40ug) Lane4:HEK293T whole cell lysate (40ug)