Nogo A (E499) polyclonal antibody

CNS white matter is selectively inhibitory for axonal out-growth. Nogo (also designated NI250 and Reticulon 4-A) is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Other members of the Reticulon protein family do not inhibit axon xtension and are thought to have a role in ER function. Nogo is expressed by oligodendrocytes but not by Schwann cells, and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo A, Nogo B and Nogo C.Nogo A and Nogo C have a molecular mass of 200-250 kDa and 22 kDa, respectively.

Reticulon-4; Reticulon 4; Foocen; Neurite outgrowth inhibitor; Nogo protein; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5; RTN4; KIAA0886; NOGO; My043; SP1507

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .