AChRα1 (E217) polyclonal antibody
Product Specifications
Background
Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junctionand bind acetylcholine molecules, allowing ions to move through thepore. Glutamate receptors are found in the postsynaptic membrane of cellsin the central nervous system. AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS or CHRNA1, is a 482 amino acid multi-pass membrane protein that exists as two alternatively spliced isoforms, which are expressed in different tissues. Isoform 1 is only expressed in skeletal muscle whereas isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Acetylcholine receptor subunit alpha; ACHRA; CHNRA; CHRNA1; ACHRD; CMS2A; FCCMS, SCCMS; Acra
Swiss Prot
P02708
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 181-230 of Human AChRα1.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
AChRα1 (E217) polyclonal antibody detects endogenous levels of AChRα1 protein.
Applications Notes
Western blot (WB) analysis of AChRα1 (E217) pAb at 1:500 dilution Lane1:HepG2 whole cell lysate (40ug) Lane2:A549 whole cell lysate (40ug) Lane3:PC3 whole cell lysate (40ug) Lane4:CT26 whole cell lysate (40ug) Lane5:H9C2 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
Curated Selection
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