NK-2R (P340) polyclonal antibody
Product Specifications
Background
Substance P (SP) and neurokinin-A (NK-A) are members of the tachykinins, and they function as modulators of the immune and hematopoietic systems. The tachykinins interact with each of three cloned neurokinin (NK) receptors (NK-1R, NK-2R, NK-3R), with SP and NK-A exhibiting binding preferences for NK-1R and NK-2R, respectively. NK-4R shares close homology with NK-3R, and both have nearly identical pharmacologicl properties. In the normal ileum and colon, NK-1R and NK-2R are localized to smooth muscle cells of the muscularis mucosae and propria and to a few inflammatory cells of the lamina propria. NK-1R expression is also found in the muscular wall of submucosal blood vessels, enteric neurons and, to a lesser degree, in surface epithelial cells. NK-3R is found in the spinal cord in both lamina X and lamina II.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Substance-K receptor; SKR; NK-2 receptor; NK-2R; Neurokinin A receptor; Tachykinin receptor 2; TACR2; NK2R, NKNAR, TAC2R
Swiss Prot
P21452
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 320-370 of Human NK-2R.
Conjugation
Unconjugated
Applications
WB IHC IF
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 44 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
NK-2R (P340) polyclonal antibody detects endogenous levels of NK-2R protein.
Applications Notes
Western blot (WB) analysis of NK-2R (P340) pAb at 1:500 dilution Lane1:CT26 whole cell lysate (40ug) Lane2:H9C2 whole cell lysate (40ug) Lane3:Hela whole cell lysate (40ug) Lane4:HCT116 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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