NK-1R (K245) polyclonal antibody

Product Specifications

Background

The neurokinin-1 (NK1) receptor is a G-protein-coupled receptor characterized by seven transmembrane helices which preferentially binds the neuropeptide substance P. NK1 receptor (also known as the Substance P Receptor) plays a key role in pain and inflammation. Studies also implicate NK1 receptor in depression and the growth of brain tumors. The NK1 receptor has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Substance-P receptor; SPR; NK-1 receptor; NK-1R; Tachykinin receptor 1; TACR1; NK1R; TAC1R

Swiss Prot

P25103

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 215-260 of Human NK-1R.

Conjugation

Unconjugated

Applications

WB IF

Dilution

WB: 1:500~1:1000 IF: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 46 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

NK-1R (K245) polyclonal antibody detects endogenous levels of NK-1R protein.

Applications Notes

Western blot (WB) analysis of NK-1R (K245) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate