CysLTR1 (C173) polyclonal antibody
Product Specifications
Background
Cysteinyl leukotriene (CysLTs) induce intracellular calcium mobilization through the binding of two distinct seven-transmembrane, G protein-coupled receptors, designated CysLT1 and CysLT2 receptors, to induce potent broncoconstriction. Airway smooth muscle and macrophages express both receptor types, and additionally monocytes and eosinophils express CysLT1 receptor, while cardiac Purkinje cells, adrenal medulla, peripheral blood leukocytes and brain also utilize CysLT2 receptor. The effects of the CysLT receptors can be blocked by antagonists, indicating a therapeutic mechanism for the treatment of asthma and allergies.
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cysteinyl leukotriene receptor 1; CysLTR1; Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81; CYSLTR1; CYSLT1
Swiss Prot
Q9Y271
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 140-189 of Human CysLTR1.
Conjugation
Unconjugated
Applications
WB IHC IF
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 38 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CysLTR1 (C173) polyclonal antibody detects endogenous levels of CysLTR1 protein.
Applications Notes
Western blot (WB) analysis of CysLTR1 (C173) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate (20ug) Lane2:MCF-7 whole cell lysate (40ug) Lane3:C6 whole cell lysate (20ug) Lane4:BV2 whole cell lysate (40ug)
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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