Prothrombin (G724) polyclonal antibody
Product Specifications
Background
Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which mediate a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Proteolytic cleavage of Prothrombin (Factor II) at residue 44 leads to formation of Thrombin in the first step of the coagulation cascade. Thrombin cleaves bonds between Arg and Gly and activates Factors V, VII, VIII and XIII in complex with thrombomodulin and Protein C. Thrombin maintains vascular integrity during development and postnatal life and coordinates connective tissue proteins by stimulating fibroblast procollagen production.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Prothrombin; Coagulation factor II; Activation peptide fragment 2; F2
Swiss Prot
P00734
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 701-750 of Human Prothrombin.
Conjugation
Unconjugated
Applications
IHC IF
Dilution
IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 70 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Prothrombin (G724) polyclonal antibody detects endogenous levels of Prothrombin protein.
Host or Source
Rabbit
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
51583141 1x10<sup>6</sup> cells/1.0ml
ZNF519 CRISPR Knock Out 293T Cell Line (Human)
Ask
View Details 
MBS6396410-01 0.1 mL
TGFB2 (Transforming Growth Factor beta-2, TGF-beta-2, BSC-1 Cell Growth Inhibitor, Cetermin, Glioblastoma-derived T-cell Suppressor Factor, G-TSF, Polyergin, MGC116892) (MaxLight 750)
Ask
View Details