BLNK (N91) polyclonal antibody
Product Specifications
Background
B-cell linker protein (BLNK, also known as SLP65, BASH, and BCA) is a B cell adaptor that plays an important role in B cell development and in BCR-signal transduction. Since BLNK does not encode any intrinsic enzymatic activity, its function is to serve as a scaffold for assembling macromolecular complexes which includes enzymes (PLC gamma, Vav and Btk) and additional linker proteins (Grb2 and Nck) (1-3) . In addition, BLNK binds Btk and is required for activation of the transcription factor NF-κB. Tyrosine phosphorylation of BLNK by Syk provides specific docking sites for these SH2-containing effector proteins which in turn permits phosphorylation and/or activation of their respective signaling pathways.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
B-cell linker protein; BASH; BASH; Bca; Bca; BLNK; BLNK s; BLNK; Cytoplasmic adapter protein; Ly 57; Ly 57; Ly57; Lymphocyte antigen 57; Lymphocyte antigen 57; Lyw 57; Lyw57; Lyw57; MGC111051; SLP 65; SLP 65; SLP-65; SLP65
Swiss Prot
Q8WV28
Reactivity
Human, Mouse
Immunogen
Synthetic peptide, corresponding to amino acids 60-107 of Human BLNK.
Conjugation
Unconjugated
Related Pathways
B cell receptor signaling
Applications
IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 68,70 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
BLNK (N91) polyclonal antibody detects endogenous levels of BLNK protein.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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