WWOX (A7) polyclonal antibody
Product Specifications
Background
WWOX (WW domain containing oxidoreductase) protein is a candidate tumor suppressor consisting of two WW domains that influence protein-protein interactions, and a short chain dehydrogenase (SDR) domain, that influences sex-steroid metabolism. Modulation of the WWOX gene influences esophageal squamous cell carcinogenesis and tumorigenicity of breast cancer cell lines MDA-MB-435 and T47D. The murine homolog WOX1 localizes in the mitochondria, and contains a mitochondrial targeting sequence mapping within the SDR domain. JNK1 can physically associate with WOX1 and sequester WOX1-dependent apoptosis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
WW domain-containing oxidoreductase; Fragile site FRA16D oxidoreductase; WWOX; FOR; WOX1
Swiss Prot
Q9NZC7
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to the N-terminual of Human WWOX.
Conjugation
Unconjugated
Applications
WB IHC IF
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 47 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
WWOX (A7) polyclonal antibody detects endogenous levels of WWOX protein.
Applications Notes
Western blot (WB) analysis of WWOX (A7) polyclonal antibody at 1:500 dilution Lane1:The Testis tissue lysate of Mouse (40ug) Lane2:The Testis tissue lysate of Rat (40ug) Lane3:SK-OVCAR3 whole cell lysate (40ug) Lane4:A2780 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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