SR-1E (A127) polyclonal antibody
Product Specifications
Background
The members of the G protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. β-adrenergic bound to adrenaline activates adenylyl cyclase, while α2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. Like the α2-adrenergic receptor, serotonin receptor functions are also mediated by G proteins that inhibit the activity of adenylyl cyclase. The serotonin receptors have been classified into several categories, designated SR-1–7 (5HT1–7) . Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
HTR1E; 5-hydroxytryptamine receptor 1E; Serotonin receptor 1E; 5-HT-1E; 5-HT1E
Swiss Prot
P28566
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to amino acids 95-140 of Human SR-1E.
Conjugation
Unconjugated
Applications
IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 42 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SR-1E (A127) polyclonal antibody detects endogenous levels of SR-1E protein.
Host or Source
Rabbit
Available Sizes
Curated Selection
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