COPS5 / JAB1 (K191) polyclonal antibody
Product Specifications
Background
Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA) -induced expression of responsive genes through the TPA-response element (TRE) . The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. The coactivator of Jun, designated JAB1 (for Junactivation
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; Jun activation domain-binding protein; COPS5; CSN5; JAB1
Swiss Prot
Q92905
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 160-212 of Human COPS5 / JAB1.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 38 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
JAB1 (K191) polyclonal antibody detects endogenous levels of JAB1 protein.
Applications Notes
Western blot (WB) analysis of COPS5/JAB1 (K191) pAb at 1:1000 dilution Lane1:A549 whole cell lysate (40ug) Lane2:MCF-7 whole cell lysate (40ug) Lane3:The Lung tissue lysate of Rat (40ug) Lane4:CT26 whole cell lysate (40ug)
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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