Cadherin-7 (R678) polyclonal antibody

The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. Cadherin-7 is a member of the atypical type II cadherin family that lacks the HAV cell recognition sequence found in type I cadherins. Although the absence of an HAV sequence decreases cell adhesion specificity, cadherin-7 contributes to cell organization by mediating homophilic cell adhesion in the brain, testis and prostate.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of Cadherin-7 (R678) pAb at 1:500 dilution Lane1:The Brain tissue lysate of Mouse (40ug) Lane2:The Brain tissue lysate of Rat (40ug)