CYP2C8/9/18/19 (M136) polyclonal antibody

The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP2C (CYPIIC) subfamily comprises a group of constitutively expressed genes, some phenobarbital-induced genes, and several genes associated with sex-specific expression. Originally, at least 7 genes were assigned to the CYP2C subfamily, which maps to human 10q24.1-q24.3 and mouse chromosome 19. Humans contain fewer genes in this cluster than do mice or rats. Four genes are arranged in the following order and orientation along human chromosome 10: RBP4, CYP2C18, CYP2C19/CYP2C9, and CYP2C8. The previsously identified CYP2C10 is an artifact of CYP2C9 and not a distinct isoform. All of the CYP2C proteins localize to the endoplasmic reticulum.

Cytochrome P450 2C9; (R) -limonene 6-monooxygenase; (S) -limonene 6-monooxygenase; (S) -limonene 7-monooxygenase; CYPIIC9; Cytochrome P-450MP; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; S-mephenytoin 4-hydroxylase; CYP2C9; CYP2C10; Cytochrome P450 2C8; CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase; CYP2C8; Cytochrome P450 2C18; CYPIIC18; Cytochrome P450-6b/29c; CYP2C18; Cytochrome P450 2C19; (R) -limonene 6-monooxygenase; (S) -limonene 6-monooxygenase; (S) -limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase; CYP2C19

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .