CYP24A1 (R439) polyclonal antibody

P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. P450 enzymes can be classified, based on their sequence similarities, into distinct subfamilies, which include CYP1A and CYP2A. The P450 family member, CYP19, catalyzes the conversion of C19 steroids to estrogens in various tissues, including placenta, gonads, adipose tissue, skin and brain. P450 cholesterol 7a-hydroxylase, CYP7A1, is the rate limiting enzyme of bile acid synthesis in the liver, and its expression is mediated by the bile acid receptor FXR. CYP27A1 catalyzes vitamin D 25-hydroxylation and is localized to the mitochondria in kidney and liver. Overexpression of CYP24 (encoding vitamin D 24 hydroxylase) is likely to lead to abrogation of growth control mediated by vitamin D.

1; 25-dihydroxyvitamin D (3) 24-hydroxylase; mitochondrial; 24-OHase; Vitamin D (3) 24-hydroxylase; Cytochrome P450 24A1; Cytochrome P450-CC24; CYP24A1; CYP24

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .