What is the catalog number for CYP17A1 (N249) polyclonal antibody?

The catalog number for CYP17A1 (N249) polyclonal antibody is BS2187.

What sizes are available for CYP17A1 (N249) polyclonal antibody?

CYP17A1 (N249) polyclonal antibody is available in the following size(s): 50 µL, 100 µL.

How many pack sizes does CYP17A1 (N249) polyclonal antibody come in?

CYP17A1 (N249) polyclonal antibody is available in 2 different pack sizes.

Is CYP17A1 (N249) polyclonal antibody in stock?

CYP17A1 (N249) polyclonal antibody is currently made to order / not held in immediate stock. Contact us for lead time.

CYP17A1 (N249) polyclonal antibody

Product Specifications

Background

CYP17A (17α-hydroxylase/17,20-lyase) is important for the conversion of pregnenolone and progesterone to dehydroepiandrosterone (DHEA) and androstenedione. In this process, it catalyzes both the 17α-hydroxylation and the 17,20-lyase reaction.CYP17A1 is crucial during sexual development, both during fetal development and during puberty, and is intracellularly regulated by cAMP levels. Defects in the CYP17A1 gene, which encodes for the protein, may cause adrenal hyperplasia type V (AH-V) which is characterized by hypokalemia and hypertension.Male patients affected by AH-V do not undergo normal sexual differentiation and develop female external genitalia and do not undergo pubertal develoment.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Steroid 17-alpha-hydroxylase/17,20 lyase; 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase; CYP17A1; CYP17; S17AH

Swiss Prot

P05093

Reactivity

Human

Immunogen

Synthetic peptide, corresponding to amino acids 211-260 of Human CYP17A1.

Conjugation

Unconjugated

Applications

WB IHC IF

Dilution

WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 57 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

CYP17A1 (N249) polyclonal antibody detects endogenous levels of CYP17A1 protein.

Applications Notes

Western blot (WB) analysis of CYP17A1 (N249) pAb at 1:500 dilution Lane1:MCF-7 whole cell lysate (40ug) Lane2:A2780 whole cell lysate (40ug) Lane3:PC3 whole cell lysate (40ug) Lane4:HEK293T whole cell lysate (40ug)