Cofilin1/2 (T88) polyclonal antibody
Product Specifications
Background
Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F-Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors such as opsonized zymosan.Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cofilin-1; Cofilin1; Cofilin 1; 18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform; CFL1; CFL; Cofilin-2; Cofilin2; Cofilin 2; Cofilin, muscle isoform; CFL2
Swiss Prot
Q9Y281/P23528
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 55-100 of Human Cofilin1.
Conjugation
Unconjugated
Related Pathways
Phosphoinosotode Signaling, Regulation of Actin Dynamics, Tumor Angiogenesis, Regulation of Microtubule Dynamics
Applications
WB IF
Dilution
WB: 1:500~1:1000 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 19 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Cofilin1/2 (T88) polyclonal antibody detects endogenous levels of Cofilin1/2 protein.
Applications Notes
Western blot (WB) analysis of Cofilin1/2 (T88) polyclonal antibody at 1:500 dilution Lane1:A549 cell lysate Lane2:Mouse heart tissue lysate Lane3:Rat heart tissue lysate
Host or Source
Rabbit
Available Sizes
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