Septin 1 (D205) polyclonal antibody
Product Specifications
Background
The septins are a family of GTPase enzymes, some of which are required for cytokinesis and others of which are associated with exocytosis. Members of the septin family can form heteropolymer complexes and also play a role in the organization of new growth in organisms. The transcriptional regulation of all septins is complex, resulting in alternatively spliced variants. At least three septins (Septin 1, 2 and 4) are associated with a Tau-based paired helical filament core and may contribute to the formation of neurofibrillary tangle as integral constituents of paired helical filaments. Septin 3 (G-Septin), a GTP-binding protein, is highly expressed in brain and is regulated by protein kinase G in neurons. The human SEPT4 (H5/PNUTL2/CDCrREL-2) gene encodes ARTS (for apoptosis-related protein in the TGFβ signaling pathway), which is expressed in many cells and acts to enhance cell death induced by TGFβ or, to a lesser extent, by other apoptotic agents.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Septin-1; LARP; Peanut-like protein 3; Serologically defined breast cancer antigen NY-BR-24; SEPT1; DIFF6; PNUTL3
Swiss Prot
Q8WYJ6
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 169-224 of Human Septin 1.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 42 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Septin 1 (D205) polyclonal antibody detects endogenous levels of Septin 1 protein.
Applications Notes
Western blot (WB) analysis of Septin 1 (D205) pAb at 1:1000 dilution Lane1:K562 whole cell lysate (40ug) Lane2:SKOVCAR3 whole cell lysate (40ug) Lane3:PC12 whole cell lysate (40ug) Lane4:3T3-L1 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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