LIMK1 (Q491) polyclonal antibody
Product Specifications
Background
Proteins containing LIM motifs are typically involved in cell fate determination and growth control. A family of proteins designated LIM kinases, including LIMK-1 and LIMK-2, has been identified. LIMK-1 has been shown to regulate the stabilization of F-Actin structures and cofilin activity, indicating that LIMK-1 plays a role in a signaling pathway involved in the regulation of cell motility and morphogenesis. LIMK-1 inhibits neuronal differentiation of PC12 cells, and is thought to act by interfering with events downstream of MAPK activation. Expression patterns of LIMK-1 and LIMK-2 suggest that these proteins may have different functions during development. A truncated form of LIMK-2 has been identified in adult testis that is thought to arise from an alternative initiation exon.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
LIM domain kinase 1; LIMK-1; LIMK1; LIMK
Swiss Prot
P53667
Reactivity
Human, Mouse
Immunogen
Synthetic peptide, corresponding to amino acids 450-500 of Human LIMK1.
Conjugation
Unconjugated
Related Pathways
Regulation of Actin Dynamics, Regulation of Microtubule Dynamics
Applications
IHC IF
Dilution
IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 72 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
LIMK1 (Q491) polyclonal antibody detects endogenous levels of LIMK1 protein. The antibody does not cross-react with LIMK2.
Host or Source
Rabbit
Available Sizes
Curated Selection
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