APRIL (S183) polyclonal antibody

A proliferation-inducing ligand (APRIL), also designated TNFSF13, is a Type II membrane protein that shares characteristics with other members of the tumor necrosis factor (TNF) cytokine family. APRIL is expressed in high levels in transformed cell lines and in human colon, thyroid, and lymphoid tumor tissues. APRIL is critically involved in the regulation of infections, inflammation, autoimmune diseases, and tissue homeostasis. APRIL is implicated in the regulation of tumor cell growth. The C-terminal extracellular domain has b jelly roll topography and is important in ligand trimerization. The binding of the ligand to its respective receptor induces oligomerization, initiating downstream signaling events. Intrinsic to oligomerization is the formation of the receptor binding site at the junction between neighboring subunits, creating a multivalent ligand.

Tumor necrosis factor ligand superfamily member 13; A proliferation-inducing ligand; APRIL; TNF- and APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; TRDL1; CD256; TNFSF13; APRIL; TALL2; ZTNF2; ORF Names: UNQ383/PRO715

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of APRIL (S183) pAb at 1:500 dilution Lane1:SGC7901 whole cell lysate (40ug) Lane2:A549 whole cell lysate (40ug) Lane3:Panc1 whole cell lysate (40ug) Lane4:H9C2 whole cell lysate (40ug) Lane5:CT26 whole cell lysate (40ug)