AURKB/C (K197) polyclonal antibody
Product Specifications
Background
Aurora kinases belong to a highly conserved family of mitotic serine/threonine kinases with three members identified among mammals: Aurora A, B, and C. Studies on the temporal expression pattern and subcellular localization of Aurora kinases in mitotic cells suggest an association with mitotic structure. Aurora kinase functional influences span from G2 phase to cytokinesis and may be involved in key cell cycle events such as centrosome duplication, chromosome bi-orientation and segregation, cleavage furrow positioning, and ingression.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Aurora kinase B; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B; AURKB; AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; Aurora kinase C; Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C; AURKC; AIE2; AIK3; AIRK3; ARK3; STK13
Swiss Prot
Q96GD4/Q9UQB9
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 163-213 of Human AURKB.
Conjugation
Unconjugated
Related Pathways
Regulation of Microtubule Dynamics
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 35, 39 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
AURKB/C (K197) polyclonal antibody detects endogenous levels of AURKB and AURKC protein.
Applications Notes
Western blot (WB) analysis of AURKB/C (K197) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate (20ug) Lane2:HepG2 whole cell lysate (20ug) Lane3:PC3 whole cell lysate (40ug) Lane4:A549 whole cell lysate (40ug) Lane5:PC12 whole cell lysate (40ug) Lane6:AML-12 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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