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MAPKAPK-2 (S328) polyclonal antibody

Product Specifications

Background

MAP kinase activated protein kinase 2 (MAPKAP Kinase 2), also known as p45 hsp27 kinase, is a 45-54 kDa serine/threonine protein kinase that contains a proline rich sequence and two putative SH3 binding sites. MAPKAP Kinase 2 is activated in response to stress, IL1 and TNF, possibly catalyzed by p38/Hog dependent phosphorylation. One of the major substrates of MAPKAP Kinase 2 is hsp27, which stimulates actin polymerization in order to facilitate recovery from destruction of cytoskeleton during cellular stresses. MAPKAP2 is implicated in several disorders including ischemic brain injury and heart failure and has been shown to be important in regulating stress resistance and the production of TNF alpha.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

MAPKAP Kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAPK-2; MK2; EC 2.7.11.1; MAPKAPK2

Swiss Prot

P49137

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 300-350 of Human MAPKAPK-2.

Conjugation

Unconjugated

Related Pathways

Regulation of Microtubule Dynamics, Signaling Pathways Activating p38 MAP KinaseMAPK Erk in Growth and Differentiation Pathway

Applications

WB IHC

Dilution

WB: 1:500~1:1000 IHC: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 46 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

MAPKAPK-2 (S328) polyclonal antibody detects endogenous levels of MAPKAPK-2 protein.

Applications Notes

Western blot (WB) analysis of MAPKAPK-2 (S328) polyclonal antibody at 1:500 dilution Lane1:C6 whole cell lysate (40ug) Lane2:The Brain tissue lysate of Rat (40ug) Lane3:The Brain tissue lysate of Mouse (40ug) Lane4:HEK293T whole cell lysate (40ug)

Host or Source

Rabbit

Available Sizes

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