Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

LKB1 (R425) polyclonal antibody

Product Specifications

Background

LKB1, a member of the serine/threonine kinase family, is a tumor suppressor. Physically associates with p53, it regulates specific p53 dependent apoptosis pathways. LKB1 protein is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. Restoring LKB1 activity into cancer cell lines defective for its expression results in a G1 cell cycle arrest.Mutations in LKB1 gene are associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19; STK11; LKB1; PJS

Swiss Prot

Q15831

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 396-442 of Human LKB1.

Conjugation

Unconjugated

Related Pathways

Warburg Effect, Translational Contral elF4 and p70 S6 Kinase, Glutamine Metabolism, AMPK Signaling Pathway, MTOR signaling

Applications

WB IHC IF

Dilution

WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 48, 54 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

LKB1 (R425) polyclonal antibody detects endogenous levels of LKB1 protein.

Applications Notes

Western blot (WB) analysis of LKB1 (R425) pAb at 1:1000 dilution Lane1:MCF-7 whole cell lysate (40ug) Lane2:H9C2 whole cell lysate (40ug) Lane3:PMVEC whole cell lysate (40ug) Lane4:The Testis tissue lysate of Mouse (40ug) Lane5:EC9706 whole cell lysate (40ug) Lane6:H1792 whole cell lysate (40ug) Lane7:SK-OVCAR3 whole cell lysate (40ug)

Host or Source

Rabbit

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

WNT8A (NM_058244) Human Over-expression Lysate
LC403304 20 µg

WNT8A (NM_058244) Human Over-expression Lysate

Sign In for Pricing
View Details
Anti-CD9 Antibody [SA35-08]
ET1601-9TR 20 µL

Anti-CD9 Antibody [SA35-08]

Sign In for Pricing
View Details
CX3CR1 Mouse Monoclonal Antibody [A5C7]
HA600074 100 µL

CX3CR1 Mouse Monoclonal Antibody [A5C7]

Sign In for Pricing
View Details
COMT Antibody (Biotin)
KB-2779-01 50 μL

COMT Antibody (Biotin)

Sign In for Pricing
View Details
COMT Antibody (Biotin)
KB-2779-02 100 µL

COMT Antibody (Biotin)

Sign In for Pricing
View Details
COMT Antibody (Biotin)
KB-2779-03 1 mL

COMT Antibody (Biotin)

Sign In for Pricing
View Details