PC-PLD1 (K556) polyclonal antibody
Product Specifications
Background
Activation of phosphatidylcholine-specific phospholipase D (PC-PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) . Insulin activates the PLD-dependent hydrolysis of PC in plasma membranes of adipocytes by a mechanism that may involve wortmannin-sensitive phosphatidylinositol 3-kinase. In addition to the transient activation by growth factors stimulation, PC-PLD is constitutively activated in some of the Src- and Ras-transformed cells. PC-PLD is one of the target enzymes of ischemia; its decrease may cause a perturbation of PC hydrolysis and/or disorders of intracellular signal transduction or choline metabolism for acetylcholine formation in the brain.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Phospholipase D1; PLD 1; hPLD1; Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1; PLD1
Swiss Prot
Q13393
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 524-573 of Human PC-PLD1.
Conjugation
Unconjugated
Applications
IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PLD1 (K556) polyclonal antibody detects endogenous levels of PLD1 protein.
Host or Source
Rabbit
Available Sizes
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