UCN (A103) polyclonal antibody
Product Specifications
Background
Urocortins 1, 2 and 3 are the mammalian homologs of fish urotensin I. Mammalian urocortin is a member of the corticotropin-releasing hormone (CRH) family that is expressed in a region of the rat midbrain. The distinct expression pattern in discrete brain regions suggests that it influences such behavior as feeding, anxiety and auditory processing. Synthetic human urocortin binds with high affinity to CRH receptors and acts in vitro to release ACTH from dispersed rat anterior pituitary cells. It is suggested that urocortin may be an endogenous CRF-like factor in the brain responsible for the effects of stress on appetite. The gene which encodes urocortin maps to human chromosome 2. Specifically, urocortin III is a specific ligand for CRF type 2 receptor which mediates stress-coping responses. Human urocortin I and III are expressed in the human heart. Urocortin III is also expressed in the pituitary gland, adrenal gland, GI tract, ovary, spleen, brain and kidney.
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Urocortin
Swiss Prot
P55089
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 80-130 of Human UCN.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 13 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Urocortin (A103) polyclonal antibody detects endogenous levels of Urocortin protein.
Applications Notes
Western blot (WB) analysis of UCN (A103) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
N002496 3 Card (3 Marker (s) x 1 Card)
GAZMIXTE355X37CARD-T1-P2 Pipe Markers for Gases
Ask
View Details 
MBS1100358-01 0.02 mg (E-Coli)
Recombinant Streptococcus gordonii Adenylosuccinate synthetase (purA)
Ask
View Details MBS1100358-02 0.02 mg (Yeast)
Recombinant Streptococcus gordonii Adenylosuccinate synthetase (purA)
Ask
View Details MBS1100358-03 0.1 mg (E-Coli)
Recombinant Streptococcus gordonii Adenylosuccinate synthetase (purA)
Ask
View Details 
MBS1100358-04 0.1 mg (Yeast)
Recombinant Streptococcus gordonii Adenylosuccinate synthetase (purA)
Ask
View Details MBS1100358-05 0.02 mg (Baculovirus)
Recombinant Streptococcus gordonii Adenylosuccinate synthetase (purA)
Ask
View Details