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Lamin A/C (R386) polyclonal antibody

Product Specifications

Background

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed CED-3/ICE, functions as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Prelamin-A/C; Lamin-A/C; Lamin A/C; LaminA/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C

Swiss Prot

P02545

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 351-400 of Human Lamin A/C.

Conjugation

Unconjugated

Applications

WB IHC IF

Dilution

WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 74, 65 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Lamin A/C (R386) polyclonal antibody detects endogenous levels of Lamin A/C protein.

Applications Notes

Western blot (WB) analysis of Lamin A/C (R386) polyclonal antibody at 1:500 dilution Lane1:HepG2 whole cell lysate (40ug) Lane2:L02 whole cell lysate (40ug) Lane3:PC12 whole cell lysate (40ug) Lane4:AML-12 whole cell lysate (40ug) Lane5:A549 whole cell lysate (40ug)

Host or Source

Rabbit

Available Sizes

Frequently Asked Questions

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