TH (Q25) polyclonal antibody
Product Specifications
Background
The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson’s disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH; TYH
Swiss Prot
P07101
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to the N-terminus of Human TH.
Conjugation
Unconjugated
Related Pathways
Neuronal and Glial Cell Marker Atlas, Dopamine Signaling in Parkinson's Disease Plathway
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 58 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Tyrosine Hydroxylase (Q25) polyclonal antibody detects endogenous levels of Tyrosine Hydroxylase protein.
Applications Notes
Western blot (WB) analysis of TH (Q25) pAb at 1:2000 dilution Lane1:The Heart tissue lysate of Mouse (40ug) Lane2:The Heart tissue lysate of Rat (40ug)
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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