NM23-H2 (H118) polyclonal antibody

The nm23 protein is the collective designation for two closely related proteins encoded by the genes nm23H1 and nm23H2 now called NME1 and NME2. The protein is expressed in the nucleus and cytoplasm of all normal cells, and on the cell surface of many haematopoietic cells, including erythrocytes. Tumour cells with a high metastatic potential often lack or express only a low amount of nm23 protein, hence the nm23 protein has been described as a metastasis suppressor protein. Recent studies, however, suggest a more complex relationship between occurrence of the nm23 protein and metastatic activity.

Nucleoside diphosphate kinase B; NDK B; NDP kinase B; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB; nm23-H2; NME2; NM23B

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of NM23-H2 (H118) pAb at 1:500 dilution Lane1:MCF-7 whole cell lysate (40ug) Lane2:HEK293T whole cell lysate (40ug) Lane3:Hela whole cell lysate (40ug) Lane4:H9C2 whole cell lysate (40ug) Lane5:BV2 whole cell lysate (40ug)