MEF-2 (I402) polyclonal antibody
Product Specifications
Background
The myocyte enhancer factor-2 (MEF-2) family of transcription factors associated with co-repessors or co-activators to regulate development and function of T cells, neuronal cells and muscle cells. Four family members arise from alternatively spliced transcripts, termed MEF-2A, -2B, -2C and -2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1; MEF2A; MEF2
Swiss Prot
Q02078
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 380-330 of Human MEF-2.
Conjugation
Unconjugated
Related Pathways
Signaling Pathways Activating p38 MAP Kinase, Examples of Crosstalk Between Post-translational Modifications
Applications
IHC IF
Dilution
IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
MEF2A (I402) polyclonal antibody detects endogenous levels of MEF2A protein.
Host or Source
Rabbit