BACE (D492) polyclonal antibody

Autosomal dominant Alzheimer’s disease is caused by mutations in the gene encoding the β-amyloid protein precursor (APP) . Amyloid β-peptide (Aβ), the major feature of amyloid plaques in Alzheimer’s patients, is the product of APP cleavage by β- and γ-secretases. BACE is the transmembrane protease which cleaves Aβ from APP. BACE and the related protein Asp1 are both widely expressed in human tissue with the highest levels in the pancreas. BACE has a molecular mass of ~70 kDa, larger than predicted due to glycosylation, and is localized within Golgi and endosomes.

Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2; BACE1; BACE; KIAA1149

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .