Synaptotagmin (M303) polyclonal antibody
Product Specifications
Background
Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Synaptotagmin-1; Synaptotagmin 1; Synaptotagmin I; SytI; SYT1; SVP65; SYT
Swiss Prot
P21579
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 280-330 of Human Synaptotagmin.
Conjugation
Unconjugated
Related Pathways
Vesicle Trafficking presynaptic signaling
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 64 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Synaptotagmin (M303) polyclonal antibody detects endogenous levels of Synaptotagmin protein.
Applications Notes
Western blot (WB) analysis of Synaptotagmin (M303) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate
Host or Source
Rabbit
Available Sizes
Curated Selection
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