Cytokeratin 10 (Y160) polyclonal antibody
Product Specifications
Background
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are present in the cytoskeletal region of a subset of squamous cell carcinomas. Cytokeratin 10 is a heterotetramer of two type I and two type II keratins, is generally associated with keratin 1, and is seen in all suprabasal cell layers including stratum corneum.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Keratin, type I cytoskeletal 10; Cytokeratin-10; Short name=CK-10; Keratin-10; Short name=K10; KRT10; KPP; CK-10; CK 10; CK10; Keratin 10; Keratin10
Swiss Prot
P13645
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 130-180 of Human Cytokeratin 10.
Conjugation
Unconjugated
Applications
IHC IF
Dilution
IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 59 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Cytokeratin 10 (Y160) polyclonal antibody detects endogenous levels of Cytokeratin 10 protein.
Host or Source
Rabbit
Available Sizes
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