What is the catalog number for ErbB2/HER2 (D871) polyclonal antibody?

The catalog number for ErbB2/HER2 (D871) polyclonal antibody is BS1172.

What sizes are available for ErbB2/HER2 (D871) polyclonal antibody?

ErbB2/HER2 (D871) polyclonal antibody is available in the following size(s): 50 µL, 100 µL.

How many pack sizes does ErbB2/HER2 (D871) polyclonal antibody come in?

ErbB2/HER2 (D871) polyclonal antibody is available in 2 different pack sizes.

Is ErbB2/HER2 (D871) polyclonal antibody in stock?

ErbB2/HER2 (D871) polyclonal antibody is currently made to order / not held in immediate stock. Contact us for lead time.

ErbB2/HER2 (D871) polyclonal antibody

Product Specifications

Background

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3), and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon hetero-dimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD340; ERBB2; HER2; MLN19; NEU; NGL

Swiss Prot

P04626

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 841-890 of Human ErbB2/HER2.

Conjugation

Unconjugated

Related Pathways

ErbB HER Signaling

Applications

WB IHC

Dilution

WB: 1:500~1:1000 IHC: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 138,185 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

ErbB2/HER2 (D871) polyclonal antibody detects endogenous levels of ErbB2/HER2 protein.

Applications Notes

Western blot (WB) analysis of HER2/Neu (D871) polyclonal antibody at 1:500 dilution Lane1:L02 whole cell lysate (40ug) Lane2:A549 whole cell lysate (40ug) Lane3:H1792 whole cell lysate (40ug) Lane4:COS-7 whole cell lysate (40ug) Lane5:HEK293T whole cell lysate (40ug) Lane6:C6 whole cell lysate (40ug) Lane7:SP2/0 whole cell lysate (40ug)