Claudin-7 (P202) polyclonal antibody
Product Specifications
Background
The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM) . Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. mRNA studies indicate that claudin-7 is specifically expressed in mouse lung and kidney, but not in heart, brain, spleen, liver, skeletal muscle or testis. The gene encoding human claudin-7 maps to chromosome 17p13.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Claudin 7; Claudin7; CLDN-7; CLDN7; CEPTRL2; CPETRL2
Swiss Prot
O95471
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 171-220 of Human Claudin-7.
Conjugation
Unconjugated
Applications
WB IHC IF IP
Dilution
WB: 1:500~1:1000 IHC/IF: 1:50~1:200 IP: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 23 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Claudin 7 (P202) polyclonal antibody detects endogenous levels of Claudin 7 protein.
Applications Notes
Western blot (WB) analysis of Claudin-7 (T202) polyclonal antibody at 1:500 dilution Lane1:HCC827 whole cell lysate (40ug) Lane2:The Lung tissue lysate of Mouse (40ug) Lane3:The Lung tissue lysate of Rat (40ug) Lane4:A549 whole cell lysate (40ug) Lane5:L02 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
Curated Selection
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