Claudin-5 (S201) polyclonal antibody
Product Specifications
Background
The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-5 is expressed in the endothelial junctions of the rat liver and in junctions of acinar cells of the pancreas. Human claudin-5 is abundantly expressed in adult lung, heart and skeletal muscle and is deleted in patients with velocardiofacial syndrone, which is characterized by cleft palate, facial dysmorphology and conotruncal heart defects.
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Claudin5; Claudin 5; Transmembrane protein deleted in VCFS; TMDVCF; CLDN5; AWAL; TMVCF
Swiss Prot
O00501
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 171-220 of Human Claudin-5.
Conjugation
Unconjugated
Applications
WB IHC IF
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 23 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Claudin 5 (S201) polyclonal antibody detects endogenous levels of Claudin 5 protein.
Applications Notes
Western blot (WB) analysis of Claudin-5 (S201) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate treated with LPS Lane2:Mouse liver tissue lysate Lane3:Rat lung tissue lysate
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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