SSB (phospho-S366) polyclonal antibody

Ro/SSA is a ribonucleoprotein that binds to autoantibodies in 35 to 50% of patients with SLE and in up to 97% of patients with Sjogren syndrome. The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules. Most anti-Ro/SSA-positive sera have antibodies not only against the immunoreactive protein, but also against an Ro/SSA protein. The genes which encode the two proteins map to human chromosomes 11p15.5 and 1q31, respectively. La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and SLE.

Autoantigen La; La; La autoantigen; La autoantigen homolog; La protein; La ribonucleoprotein; La ribonucleoprotein domain family member 3; LA; LARP3; Lupus La antigen; Lupus La protein; Lupus La protein homolog; mRNA for autoantigen; Sjoegren syndrome type B antigen; Sjoegren syndrome type B antigen; Sjogren syndrome antigen B; SS B; SS-B; SS-B/La protein; SSB

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 110% (by SDS-PAGE) .

Western blot (WB) analysis of p-SSB (S366) polyclonal antibody at 1:1000 dilution Lane1:HEK293T whole cell lysate Lane2:HEK293T treated with EGF (0.1ng/ml,15min) whole cell lysate Lane3:HEK293T treated with EGF (0.1ng/ml,30min) whole cell lysate Lane4:HEK293T treated with EGF (0.1ng/ml,60min) whole cell lysate