GFAP (phospho-Ser38) polyclonal antibody
Product Specifications
Background
Glial fibrillary acidic protein, or GFAP, is an intermediate filament (IF) protein belonging to the type III subclass of IF proteins. Like other IF proteins, GFAP is composed of an amino-terminal head domain, a central rod domain and a carboxy-terminal tail domain. GFAP is specifically found in astroglia, a cell type which is highly responsive to neurologic insults. Astrogliosis is found to be a result of mechanical trauma, AIDS dementia, prion infection and inflammatory demylination diseases, and is accompanied by an increase in GFAP expression. GFAP is an immunohistochemical marker for localizing benign astrocyte and neoplastic cells of glial origin in the central nervous system
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Glial fibrillary acidic protein
Swiss Prot
P14136
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human GFAP around the phosphorylation site of Serine 38.
Conjugation
Unconjugated
Related Pathways
Neuronal and Glial Cell Marker Atlas
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-GFAP (Ser38) polyclonal antibody detects endogenous levels of GFAP protein when phosphorylated at Ser38.
Applications Notes
Western blot (WB) analysis of p-GFAP (Ser38) pAb at 1:500 dilution Lane1:The Brain tissue lysate of Rat (30ug) Lane2:The Brain tissue lysate of Mouse (40ug)
Host or Source
Rabbit
Available Sizes
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