TWIST1 (M1) polyclonal antibody
Product Specifications
Background
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Twist-related protein 1; Class A basic helix-loop-helix protein 38; bHLHa38; H-twist; BHLHA38; TWIST
Swiss Prot
Q15672
Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to amino acids 1-50 of Human TWIST1.
Conjugation
Unconjugated
Related Pathways
Contribution of Soluble Factors to EMT
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 22 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TWIST1 (M1) polyclonal antibody detects endogenous levels of TWIST1 protein.
Applications Notes
Western blot (WB) analysis of TWIST1 (M1) polyclonal antibody at 1:500 dilution Lane1:Jurkat whole cell lysate (40ug) Lane2:RAW264.7 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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