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SIRT2 polyclonal antibody

Product Specifications

Background

SIRT2 is a member of the sirtuin family of proteins. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT2 interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. SIRT2 is a NAD-dependent deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

NAD-dependent protein deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; SIR2-like protein 2; SIRT2; SIR2L; SIR2L2

Swiss Prot

Q8IXJ6

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 330-380 of Human SIRT2.

Conjugation

Unconjugated

Related Pathways

Mitochondrial Control of Apoptosis, Epigenetic Writers and Erasers of Histone H3, Epigenetic Writers and Erasers of Histones H2A H2B and H4

Applications

WB

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 43 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

SIRT2 polyclonal antibody detects endogenous levels of SIRT2 protein.

Applications Notes

Western blot (WB) analysis of SIRT2 pAb at 1:500 dilution Lane1:U-87MG whole cell lysate (40ug) Lane2:PC12 whole cell lysate (40ug) Lane3:AML-12 whole cell lysate (40ug) Lane4:HEK293T whole cell lysate (40ug)

Host or Source

Rabbit

Available Sizes

Curated Selection

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