TNFAIP8L1 polyclonal antibody
Product Specifications
Background
Tumor necrosis factor, α-induced protein 8-like 1, also known as TNFα-IP 8L1, is a 186 amino acid protein belonging to the TNFα-IP 8 family. Members of the TNFα-IP 8 family are induced by nuclear factor-κB 9 (NFκB) and tumor necrosis factor (TNF), although induction by TNF is dependent upon NFκB activation. TNFα-IP 8 proteins also act as a negative mediator of apoptosis and may play a role in tumor progression. They suppress TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Tumor necrosis factor alpha-induced protein 8-like protein 1; TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1; TNFAIP8L1
Swiss Prot
Q8WVP5
Reactivity
Human
Immunogen
A synthetic peptide corresponding to residues in Human TNFAIP8L1
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 21 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TNFAIP8L1 polyclonal antibody detects endogenous levels of TNFAIP8L1 protein.
Applications Notes
Western blot (WB) analysis of TNFAIP8L1 pAb at 1:500 dilution Lane1:A549 whole cell lysate (40ug) Lane2:HepG2 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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