TRAIL/ TNFSF10 polyclonal antibody

Tumor necrosis factor (TNF) -related apoptosis-inducing ligand (TRAIL), also referred to as Apo2 ligand, first identified based on its sequence homology to TNF and Fas/Apo ligand is a member of the TNF family of cytokines and either exists as a type II membrane or soluble protein. TRAIL induces apoptosis in a variety of transformed cell lines and plays a role in anti-tumor and anti-viral immune surveillance. TRAIL signals via binding with death receptors DR4 (TRAIL-R1) (4) and DR5 (TRAIL-R2) which can trigger apoptosis as well as NF-κB activation.

TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; Apo-2L; CD253 antigen; TRAIL; 8743; TNFSF10; 603598; P50591; APO2L; Apo-2L; TL2; TRAIL

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .