SNRPB polyclonal antibody
Product Specifications
Background
MRNA precursors are processed in the spliceosome, where introns are excised to form continuous coding sequences. The major components of the spliceosome are RNA-protein complexes called snRNPs (small nuclear ribonucleoprotein particles) . The core proteins that are common to all snRNPs are called the Sm proteins, and are designated B, B’, D1, D2, D3, E, F and G. Antibodies recognizing Sm proteins are frequently generated in autoimmune diseases, including in patients with systemic lupus erythematosus. Sm proteins are characterized by a conserved Sm sequence motif in two parts, Sm1 and Sm2, which are separated by a variable region .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Small nuclear ribonucleoprotein-associated proteins B and B'; snRNP-B; Sm protein B/B'; Sm-B/B'; SmB/B'; SNRPB; COD; SNRPB1
Swiss Prot
P14678
Reactivity
Human, Mouse
Immunogen
Recombinant full length Human SNRPB.
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB 1:2000 - 1:5000 IHC 1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 30 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SNRPB polyclonal antibody detects endogenous levels of SNRPB protein.
Applications Notes
Western blot analysis of extracts of various cell lines, using SNRPB antibody at 1:3000 dilution.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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