PSIP1 polyclonal antibody
Product Specifications
Background
The lens epithelium-derived growth factor (LEDGF), also designated p75p52, is a transcriptional coactivator that complexes with the human immunodeficiency virus type 1 (HIV-1) integrase. LEDGF/p75p52 is essential for the nuclear localization and chromosomal association of viral proteins. As the primary integrase-to-chromatin tethering factor for HIV-1, LEDGF/p75p52 is responsible for the cellular trafficking of lentiviral integrases. During apoptosis, LEDGF/p75p52 is cleaved at three sites by caspase-3 and caspase-7, contributing to the pathogenesis of atopic disorders.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
P52; p75; PAIP; DFS70; LEDGF; PSIP2
Swiss Prot
O75475
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human PSIP1.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB 1:500 - 1:2000 IHC 1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
Refer to figures
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PSIP1 polyclonal antibody detects endogenous levels of PSIP1 protein.
Applications Notes
Immunohistochemistry of paraffin-embedded rat testis using PSIP1 antibody.
Host or Source
Rabbit
Available Sizes
Curated Selection
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