SOCS3 polyclonal antibody

Product Specifications

Background

The SOCS (suppressor of cytokine signaling) gene family consists of a group of proteins that negatively regulate cytokine signal transduction. The SOCS family proteins contain a central SH2 domain and a carboxy-terminal region termed the “SOCS box.” The SOCS-1 (also called SSI-1 and JAB), SOCS-2 (also called SSI-2 and CIS2) and SOCS-3 (also called SSI-3 and CIS3) genes are known to be upregulated by IL-6 and other cytokines. SOCS-4, SOCS-5, SOCS-6 and SOCS-7 were identified by their sequence homology with the SOCS box. CIS (for cytokine-inducible SH2-containing protein) is also a member of the SOCS family.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Suppressor of cytokine signaling 3; SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3; SOCS3; CIS3; SSI3

Swiss Prot

O14543

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant full length Human SOCS3.

Conjugation

Unconjugated

Applications

WB, IHC, IF

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .